Product Name
AKR1C4, Polyclonal Antibody
Full Product Name
Human AKR1C4 Polyclonal Antibody
Product Synonym Names
CHDR; 1.1.1.357; 1.1.1.225; 3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I; Chlordecone reductase; Dihydrodiol dehydrogenase 4; HAKRA; CDR; DD-4
Product Gene Name
anti-AKR1C4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P17516
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human AKR1C4 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-AKR1C4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AKR1C4 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for AKR1C4. It may not necessarily be applicable to this product.
NCBI GenBank Nucleotide #
NP_001809.3
[Other Products]
UniProt Primary Accession #
P17516
[Other Products]
UniProt Related Accession #
P17516[Other Products]
NCBI Official Full Name
aldo-keto reductase family 1 member C4
NCBI Official Synonym Full Names
aldo-keto reductase family 1 member C4
NCBI Official Symbol
AKR1C4??[Similar Products]
NCBI Official Synonym Symbols
C11; CDR; DD4; CHDR; DD-4; HAKRA; 3-alpha-HSD
??[Similar Products]
NCBI Protein Information
aldo-keto reductase family 1 member C4
UniProt Protein Name
Aldo-keto reductase family 1 member C4
UniProt Synonym Protein Names
3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I (EC:1.1.1.357); Chlordecone reductase (EC:1.1.1.225); CDR; Dihydrodiol dehydrogenase 4; DD-4; DD4; HAKRA
Protein Family
Aldo-keto reductase family
UniProt Gene Name
AKR1C4??[Similar Products]
UniProt Synonym Gene Names
CHDR; CDR; DD-4; DD4??[Similar Products]
UniProt Entry Name
AK1C4_HUMAN
NCBI Summary for AKR1C4
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
UniProt Comments for AKR1C4
AKR1C4: Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20- alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. Defects in AKR1C4 are a cause of 46,XY sex reversal type 8 (SRXY8). A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. AKR1C4 mutations may act as modifier of disease severity in SRXY8 patients. A splicing mutation resulting in loss of exon 2 has been found in affected individuals also carrying mutation Val-79 in AKR1C2 (PubMed:21802064). Belongs to the aldo/keto reductase family.
Protein type: Lipid Metabolism - androgen and estrogen; Oxidoreductase; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - primary bile acid biosynthesis; EC 1.1.1.357; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.225
Chromosomal Location of Human Ortholog: 10p15.1
Cellular Component: cytoplasm; cytosol
Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; electron carrier activity; aldo-keto reductase activity; chlordecone reductase activity; 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; bile acid transmembrane transporter activity; retinal dehydrogenase activity
Biological Process: steroid metabolic process; bile acid and bile salt transport; bile acid biosynthetic process; phototransduction, visible light; bile acid metabolic process; androgen metabolic process; retinoid metabolic process
Disease: 46,xy Sex Reversal 8
Research Articles on AKR1C4
1. the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
Precautions
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Disclaimer
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