Anti-ADAM22(extracellular)

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

Mouse

This antibody recognizes mouse, rat, and human (weak) ADAM22. It does not cross-react with ADAM11.

This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freeze-thaw cycles.

Small volumes of anti-ADAM22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ADAM22 is a member of the ADAM gene family which bind integrin and may play a role in cell-to-cell or cell-to-matrix interations. ADAM22 is unique in that it is only observed in the nervous system and predominantly in brain. ADAM22 is attached by cytoskeletal scaffolds to the postsynaptic density and is a receptor for LGI1.

Neuroscience and Signal Transduction Antibodies

Immunoblot (IB)

Immunoblotting: Use at 1ug/ml.

Predicted molecular weight is ~90kDa.

ADAM metallopeptidase domain 22

disintegrin and metalloproteinase domain-containing protein 22

Disintegrin and metalloproteinase domain-containing protein 22

MDC2; ADAM 22??[Similar Products]

ADA22_HUMAN

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]

ADAM22: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: axon; integral to membrane; plasma membrane

Molecular Function: integrin binding; metalloendopeptidase activity; protein binding; zinc ion binding

Biological Process: ***** locomotory behavior; cell adhesion; central nervous system development; myelination in the peripheral nervous system; negative regulation of cell adhesion; proteolysis

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