Product Name
ARMS2, siRNA
Full Product Name
ARMS2 siRNA (Human)
Product Synonym Names
Age-related maculopathy susceptibility protein 2
Product Gene Name
ARMS2 sirna
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P0C7Q2
Specificity
ARMS2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human ARMS2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Other Notes
Small volumes of ARMS2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ARMS2 sirna
siRNA to inhibit ARMS2 expression using RNA interference
Applications Tested/Suitable for ARMS2 sirna
RNA Interference (RNAi)
NCBI/Uniprot data below describe general gene information for ARMS2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001093137.1
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NCBI GenBank Nucleotide #
NM_001099667.1
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UniProt Primary Accession #
P0C7Q2
[Other Products]
UniProt Secondary Accession #
B2Y7I5[Other Products]
UniProt Related Accession #
P0C7Q2[Other Products]
Molecular Weight
11,437 Da
NCBI Official Full Name
age-related maculopathy susceptibility protein 2
NCBI Official Synonym Full Names
age-related maculopathy susceptibility 2
NCBI Official Symbol
ARMS2??[Similar Products]
NCBI Official Synonym Symbols
ARMD8
??[Similar Products]
NCBI Protein Information
age-related maculopathy susceptibility protein 2
UniProt Protein Name
Age-related maculopathy susceptibility protein 2
Protein Family
Age-related maculopathy susceptibility protein
UniProt Gene Name
ARMS2??[Similar Products]
UniProt Entry Name
ARMS2_HUMAN
NCBI Summary for ARMS2
This gene encodes a protein that is thought to play a role in diseases in the elderly. Mutations in this gene have been associated with age-related macular degeneration. [provided by RefSeq, Oct 2008]
UniProt Comments for ARMS2
ARMS2: Defects in ARMS2 influence susceptibility to age-related macular degeneration type 8 (ARMD8). ARMD is the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch's membrane. ARMD is likely to be a mechanistically heterogeneous group of disorders, and the specific disease mechanisms that underlie the vast majority of cases are currently unknown. However, a number of studies have suggested that both genetic and environmental factors are likely to play a role.
Chromosomal Location of Human Ortholog: 10q26.13
Cellular Component: photoreceptor inner segment; mitochondrion
Biological Process: retinal homeostasis
Disease: Macular Degeneration, Age-related, 8
Research Articles on ARMS2
1. Patients carrying 4 risk alleles in CFH and ARMS2 developed neovascular AMD 12.2 (95% CI, 6.2-18.3) years earlier than patients with zero risk alleles (P < .001).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
