Full Product Name
CSB Polyclonal Antibody
Product Gene Name
anti-CSB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q03468
Other Notes
Small volumes of anti-CSB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CSB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000115.1
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NCBI GenBank Nucleotide #
NM_000124.3
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UniProt Primary Accession #
Q03468
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UniProt Secondary Accession #
Q5W0L9; D3DX94; E7EV46[Other Products]
UniProt Related Accession #
P0DP91; Q03468[Other Products]
Molecular Weight
119,487 Da
NCBI Official Full Name
DNA excision repair protein ERCC-6 isoform 2
NCBI Official Synonym Full Names
ERCC excision repair 6, chromatin remodeling factor
NCBI Official Symbol
ERCC6??[Similar Products]
NCBI Official Synonym Symbols
CSB; CKN2; COFS; ARMD5; COFS1; POF11; RAD26; UVSS1; CSB-PGBD3
??[Similar Products]
NCBI Protein Information
DNA excision repair protein ERCC-6; ERCC6-PGBD3 fusion protein
UniProt Protein Name
DNA excision repair protein ERCC-6
UniProt Synonym Protein Names
ATP-dependent helicase ERCC6; Cockayne syndrome protein CSB
Protein Family
DNA excision repair protein
UniProt Gene Name
ERCC6??[Similar Products]
UniProt Synonym Gene Names
CSB??[Similar Products]
NCBI Summary for CSB
This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. [provided by RefSeq, Mar 2016]
UniProt Comments for CSB
Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA. It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to the at sites of RNA polymerase II-blocking lesions.
Research Articles on CSB
1. ERCC6 rs1917799, ERCC8 rs158572 and rs158916 demonstrated pairwise epistatic interactions to associate with chronic atrophic gastritis and gastric cancer risk. The ERCC6 rs1917799-ERCC8 rs158572 pair significantly influence ERCC6 and ERCC6-ERCC8 expression.
Precautions
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