Full Product Name
Rabbit Polyclonal to Human EMX2
Product Synonym Names
Anti-EMX2 Antibody (Internal) IHC-plus; EMX2; Empty spiracles homeobox 2; Empty spiracles-like protein 2; Homeobox protein EMX2; Empty spiracles homolog 2; Human EMX2
Product Gene Name
anti-EMX2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q04743
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
An 16 amino acid peptide near the amino terminus of human EMX2.
Immunogen Type
Synthetic peptide
Immunogen
EMX2 antibody was raised against an 16 amino acid peptide near the amino terminus of human EMX2.
Antigen Modification
Internal
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Other Notes
Small volumes of anti-EMX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-EMX2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-EMX2 antibody
IHC-P (5 ug/ml)
Immunohistochemistry (IHC) of anti-EMX2 antibody
Anti-EMX2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunohistochemistry (IHC) of anti-EMX2 antibody
Anti-EMX2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
NCBI/Uniprot data below describe general gene information for EMX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004089.1
[Other Products]
NCBI GenBank Nucleotide #
NM_004098.3
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UniProt Primary Accession #
Q04743
[Other Products]
UniProt Secondary Accession #
Q96NN8; Q9BQF4; G3V305[Other Products]
UniProt Related Accession #
Q04743[Other Products]
Molecular Weight
18,518 Da
NCBI Official Full Name
homeobox protein EMX2 isoform 1
NCBI Official Synonym Full Names
empty spiracles homeobox 2
NCBI Official Symbol
EMX2??[Similar Products]
NCBI Protein Information
homeobox protein EMX2; empty spiracles homolog 2; empty spiracles-like protein 2
UniProt Protein Name
Homeobox protein EMX2
UniProt Synonym Protein Names
Empty spiracles homolog 2; Empty spiracles-like protein 2
Protein Family
Homeobox protein
UniProt Gene Name
EMX2??[Similar Products]
UniProt Entry Name
EMX2_HUMAN
NCBI Summary for EMX2
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and ***** olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]
UniProt Comments for EMX2
EMX2: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Defects in EMX2 are the cause of schizencephaly (SCHZC). Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro- spinal fluid. Belongs to the EMX homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 10q26.1
Cellular Component: nucleus
Molecular Function: protein binding; sequence-specific DNA binding
Biological Process: neuron differentiation; forebrain cell migration; anterior/posterior pattern formation; response to drug; dentate gyrus development; regulation of transcription, DNA-dependent; cell proliferation in forebrain; cerebral cortex regionalization
Disease: Schizencephaly
Research Articles on EMX2
1. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer
Precautions
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Disclaimer
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