Product Synonym Names
RP44
Product Gene Name
anti-RGR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P47804
Species Reactivity
Human, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human RGR
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-RGR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RGR antibody
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications Tested/Suitable for anti-RGR antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RGR antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for RGR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001012738.1
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NCBI GenBank Nucleotide #
NM_001012720.1
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UniProt Primary Accession #
P47804
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UniProt Secondary Accession #
Q96FC5; A6NKK7[Other Products]
UniProt Related Accession #
P47804[Other Products]
NCBI Official Full Name
RPE-retinal G protein-coupled receptor isoform 2
NCBI Official Synonym Full Names
retinal G protein coupled receptor
NCBI Official Symbol
RGR??[Similar Products]
NCBI Official Synonym Symbols
RP44
??[Similar Products]
NCBI Protein Information
RPE-retinal G protein-coupled receptor
UniProt Protein Name
RPE-retinal G protein-coupled receptor
Protein Family
RPE-retinal G protein-coupled receptor
UniProt Gene Name
RGR??[Similar Products]
NCBI Summary for RGR
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for RGR
Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.
Research Articles on RGR
1. study to systemically analyze the potential role of variants of RGR in retinal diseases results of the suggested that the heterozygous truncation variants in RGR were less likely to be pathogenic
Precautions
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Disclaimer
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