Full Product Name
RGR Antibody
Product Gene Name
anti-RGR antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P47804
Specificity
RGR Antibody detects endogenous levels of total RGR protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human RGR.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-RGR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-RGR antibody
Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-RGR antibody
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:1000
Immunofluorescence (IF) of anti-RGR antibody
Immunofluorescence analysis of MCF7 cells, using RGR Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemistry (IHC) of anti-RGR antibody
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using RGR Antibody. The picture on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for RGR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001012738.1
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NCBI GenBank Nucleotide #
NM_001012720.1
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UniProt Primary Accession #
P47804
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UniProt Secondary Accession #
Q96FC5; A6NKK7[Other Products]
UniProt Related Accession #
P47804[Other Products]
NCBI Official Full Name
RPE-retinal G protein-coupled receptor isoform 2
NCBI Official Synonym Full Names
retinal G protein coupled receptor
NCBI Official Symbol
RGR??[Similar Products]
NCBI Official Synonym Symbols
RP44
??[Similar Products]
NCBI Protein Information
RPE-retinal G protein-coupled receptor
UniProt Protein Name
RPE-retinal G protein-coupled receptor
Protein Family
RPE-retinal G protein-coupled receptor
UniProt Gene Name
RGR??[Similar Products]
NCBI Summary for RGR
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for RGR
Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.
Research Articles on RGR
1. study to systemically analyze the potential role of variants of RGR in retinal diseases results of the suggested that the heterozygous truncation variants in RGR were less likely to be pathogenic
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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