FKHR; forkhead box O1A (FKHR); Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; FOXO1

For Research Use Only. Not for use in diagnostic procedures.

One 96-Well Plate

Store at 4 degree C.

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Small volumes of FKHR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9500963 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the FKHR, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FKHR. The ELISA analytical biochemical technique of the MBS9500963 kit is based on FKHR antibody-FKHR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FKHR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FKHR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Cell Based ELISA Kit

69 kDa

forkhead box O1

forkhead box protein O1

Forkhead box protein O1

FKHR; FOXO1A??[Similar Products]

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]

FOXO1A: a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain.

Protein type: DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 13q14.11

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm; nucleus

Molecular Function: beta-catenin binding; chromatin binding; protein binding; protein phosphatase 2A binding; sequence-specific DNA binding; ubiquitin protein ligase binding

Biological Process: anatomical structure morphogenesis; apoptosis; autophagy; blood vessel development; cell differentiation; cell glucose homeostasis; cellular response to cold; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to hydrogen peroxide; cellular response to hyperoxia; cellular response to insulin stimulus; cellular response to nitric oxide; cellular response to oxidative stress; cellular response to starvation; endocrine pancreas development; fat cell differentiation; insulin receptor signaling pathway; negative regulation of apoptosis; negative regulation of canonical Wnt signaling pathway; negative regulation of fat cell differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of gluconeogenesis; positive regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein amino acid acetylation; protein kinase B signaling; regulation of energy homeostasis; regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter; regulation of neural precursor cell proliferation; regulation of reactive oxygen species metabolic process; response to fluoride; thermoregulation; transcription, DNA-dependent

Disease: Rhabdomyosarcoma 2

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