Monoclonal Antibody to Human Antithrombin

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_000001.10 (173872942..173886516, complement). Location: 1q23-q25.1

Monoclonal

IgG1

BDI205

Host: Mouse. Hybridization of NS-1 myeloma cells with spleen cells from BALB/c mice.
Source: Ascites

Antithrombin
Binds human Antithrombin in ELISA and immunoblots. It also binds human and baboon Antithrombin in plasma. Does not react with Antithrombin found in bovine, dog or rabbit plasma. Antibody inhibits plasma ATIII activity in chromogenic thromb

Gel filtration and anion exchange

Purified, Lyophilized.
Reconstitute with 0.5ml distilled water.

1mg/ml (OD280nm, E^0.1% = 1.4) (prior to lyophilization) (lot specific)

Store lyophilized product at -20 degree C. After reconstitution, store (up to 30 days) at 2 to 8 degree C or aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-SERPINC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Monoclonal Antibodies to Platelets and Hemostasis Antigens

Detection of human Antithrombin by ELISA and immunoblotting. Recommended dilution 1-5ug/ml. Purification of plasma Antithrombin when coupled to sepharose. Each laboratory should determine an optimum working titer for use in its particular application. Oth

52,602 Da[Similar Products]

serpin peptidase inhibitor, clade C (antithrombin), member 1

antithrombin-III; serpin C1; antithrombin III; OTTHUMP00000035393; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1

Antithrombin-III

AT3??[Similar Products]

ANT3_HUMAN

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq]

Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subcellular location: Secreted ? extracellular space.

Tissue specificity: Found in plasma. Ref.21

Post-translational modification: Phosphorylation sites are present in the extracelllular medium.

Involvement in disease: Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [

MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Ref.3 Ref.12 Ref.13 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.36 Ref.37 Ref.38 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56 Ref.57 Ref.59 Ref.60 Ref.61 Ref.62 Ref.63 Ref.64 Ref.65 Ref.66

Sequence similarities: Belongs to the serpin family.

Mass spectrometry: Molecular mass is 57863 Da from positions 33 - 464. Determined by ESI. Ref.13Molecular mass is 57911 Da from positions 33 - 464. Determined by ESI. Variant Thr-414. Ref.13

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.