Mouse RPE-retinal G protein-coupled receptor (RGR) ELISA kit; RP44; RGR-opsin; RPE retinal G-protein coupled receptor; retinal G-protein coupled receptor; retinal G protein coupled receptor

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of RGR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9335732 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the retinal G protein coupled receptor (RGR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RGR. The ELISA analytical biochemical technique of the MBS9335732 kit is based on RGR antibody-RGR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RGR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RGR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

32,127 Da

retinal G protein coupled receptor

RPE-retinal G protein-coupled receptor; RGR opsin

RPE-retinal G protein-coupled receptor

RGR_MOUSE

The gene is a member of the opsin family of G-protein coupled receptors. The encoded protein is expressed in the retina, and acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Disruption of a similar gene in human is associated with autosomal recessive (arRP) and autosomal dominant retinitis pigmentosa (adRP). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

RGR: Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism. Defects in RGR are the cause of retinitis pigmentosa type 44 (RP44). RP44 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Cellular Component: membrane; integral to plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; signal transducer activity; chemokine receptor activity; photoreceptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; visual perception; response to stimulus; phototransduction; chemotaxis; signal transduction; protein-chromophore linkage

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