Product Name
Sodium channel subunit beta-1 (Scn1b), Recombinant Protein
Full Product Name
Recombinant Mouse Sodium channel subunit beta-1 (Scn1b)
Product Synonym Names
Sodium channel subunit beta-1
Product Gene Name
Scn1b recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
19-160
Sequence
GG CVEVDSDTEA VYGMTFKILC ISCKRRSETT AETFTEWTFR QKGTEEFVKI LRYENEVLQL EEDERFEGRV VWNGSRGTKD LQDLSIFITN VTYNHSGDYE CHVYRLLFFD NYEHNTSVVK KIHLEVVDKA NRDMASIVSE
3D Structure
ModBase 3D Structure for P97952
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Scn1b recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Scn1b. It may not necessarily be applicable to this product.
NCBI Accession #
NP_035452.1
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NCBI GenBank Nucleotide #
NM_011322.2
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UniProt Primary Accession #
P97952
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UniProt Related Accession #
P97952[Other Products]
Molecular Weight
24,650 Da
NCBI Official Full Name
sodium channel subunit beta-1
NCBI Official Synonym Full Names
sodium channel, voltage-gated, type I, beta
NCBI Official Symbol
Scn1b??[Similar Products]
NCBI Protein Information
sodium channel subunit beta-1; sodium channel, voltage-gated, type I, beta polypeptide
UniProt Protein Name
Sodium channel subunit beta-1
Protein Family
Sodium channel
UniProt Gene Name
Scn1b??[Similar Products]
UniProt Entry Name
SCN1B_MOUSE
UniProt Comments for Scn1b
SCN1B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1). Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in SCN1B are the cause of Brugada syndrome type 5 (BRGDA5). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, sodium; Membrane protein, integral
Cellular Component: voltage-gated sodium channel complex; membrane; T-tubule; integral to membrane
Molecular Function: sodium channel inhibitor activity; protein binding; sodium channel regulator activity; voltage-gated sodium channel activity; voltage-gated ion channel activity; sodium channel activity
Biological Process: membrane depolarization; axon guidance; transport; action potential propagation; corticospinal neuron axon guidance; sodium ion transport; ion transport; regulation of sodium ion transport; locomotion; response to pyrethroid; cardiac muscle contraction
Research Articles on Scn1b
1. Scn1b mutant subicular and layer 2/3 pyramidal neurons had increased action potential firing rates, presumably as a consequence of their increased input resistance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
