Full Product Name
AFG1L Antibody - C-terminal region
Product Gene Name
anti-AFG1L antibody
[Similar Products]
Product Synonym Gene Name
AFG1; LACE1; c222389[Similar Products]
Antibody/Peptide Pairs
AFG1L peptide (MBS3242455) is used for blocking the activity of AFG1L antibody (MBS3217560)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: MDDLGLSQDS AEGLSMFTGE EEIFAFQRTI SRLTEMQTEQ YWNEGDRTKK
3D Structure
ModBase 3D Structure for Q8WV93
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 93%; Dog: 93%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 79%; Rabbit: 93%; Rat: 79%; Zebrafish: 82%
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human LACE1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-AFG1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AFG1L antibody
This is a rabbit polyclonal antibody against LACE1. It was validated on Western Blot
Target Description: This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor s are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants.
Product Categories/Family for anti-AFG1L antibody
Polyclonal;
Applications Tested/Suitable for anti-AFG1L antibody
Western Blot (WB)
Western Blot (WB) of anti-AFG1L antibody
Host: Rabbit
Target Name: LACE1
Sample Type: HT1080 Whole Cell lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for AFG1L. It may not necessarily be applicable to this product.
NCBI Accession #
NP_660358
[Other Products]
NCBI GenBank Nucleotide #
NM_145315
[Other Products]
UniProt Primary Accession #
Q8WV93
[Other Products]
UniProt Related Accession #
Q8WV93[Other Products]
NCBI Official Full Name
AFG1-like ATPase isoform a
NCBI Official Synonym Full Names
AFG1 like ATPase
NCBI Official Symbol
AFG1L??[Similar Products]
NCBI Official Synonym Symbols
AFG1; LACE1; c222389
??[Similar Products]
NCBI Protein Information
AFG1-like ATPase
UniProt Protein Name
Lactation elevated protein 1
UniProt Synonym Protein Names
Protein AFG1 homolog
UniProt Gene Name
LACE1??[Similar Products]
UniProt Synonym Gene Names
AFG1??[Similar Products]
UniProt Entry Name
LACE1_HUMAN
NCBI Summary for AFG1L
This gene encodes a mitochondrial integral membrane protein that plays a role in mitochondrial protein homeostasis. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. It functions to mediate the degradation of nuclear-encoded complex IV subunits. Two conserved estrogen receptor s are located within 2.5 kb of this gene. Polymorphisms in this gene have been associated with bipolar disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Research Articles on AFG1L
1. Increased expression of LACE1 partitions p53 to mitochondria, causes reduction in nuclear p53 content and induces apoptosis. Thus, LACE1 mediates mitochondrial translocation of p53 and its transcription-independent apoptosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
