Homeobox protein SIX3; Sine oculis homeobox homolog 3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of SIX3 protein.

The antibody was purified by immunogen affinity chromatography.

Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Small volumes of anti-SIX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal antibody to SIX3

Western Blot (WB)

WB (1/500 - 1/1000)

Western blot analysis of SIX3 expression in HeLa (A), Jurkat (B), Raw264.7 (C), PC12 (D) whole cell lysates.

35,487 Da

SIX homeobox 3

homeobox protein SIX3; sine oculis homeobox homolog 3

Homeobox protein SIX3

SIX3_HUMAN

This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]

SIX3: May be involved in visual system development. Defects in SIX3 are the cause of holoprosencephaly type 2 (HPE2). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the SIX/Sine oculis homeobox family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: nucleus

Molecular Function: protein binding; histone deacetylase binding; transcription coactivator activity; transcription factor activity

Biological Process: lens development in camera-type eye; transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; epithelial cell maturation; cell proliferation in forebrain; neuroblast differentiation; proximal/distal axis specification; forebrain dorsal/ventral pattern formation; telencephalon regionalization; circadian behavior; regulation of cell proliferation; negative regulation of neuron differentiation; telencephalon development; eye development; visual perception; pituitary gland development; protein import into nucleus, translocation; forebrain anterior/posterior pattern formation; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent

Disease: Schizencephaly; Holoprosencephaly 2

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