Homeobox protein SIX3; Sine oculis homeobox homolog 3; SIX3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This SIX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the Central region of human SIX3.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-SIX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the sine oculis homeobox
transcription factor family. The encoded protein plays a role in
eye development. Mutations in this gene have been associated with
holoprosencephaly type 2.

Crown Antibodies; Neuroscience

Western Blot (WB), ELISA (EIA)

WB~~1:1000

SIX3 Antibody (Center) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the SIX3 antibody detected the SIX3 protein (arrow).

35487

SIX homeobox 3

homeobox protein SIX3

Homeobox protein SIX3

SIX3_HUMAN

This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]

SIX3: May be involved in visual system development. Defects in SIX3 are the cause of holoprosencephaly type 2 (HPE2). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the SIX/Sine oculis homeobox family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: nucleus

Molecular Function: protein binding; histone deacetylase binding; transcription coactivator activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; lens development in camera-type eye; negative regulation of Wnt receptor signaling pathway; epithelial cell maturation; cell proliferation in forebrain; proximal/distal axis specification; neuroblast differentiation; forebrain dorsal/ventral pattern formation; telencephalon regionalization; circadian behavior; regulation of cell proliferation; negative regulation of neuron differentiation; telencephalon development; visual perception; eye development; protein import into nucleus, translocation; pituitary gland development; forebrain anterior/posterior pattern formation; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent

Disease: Schizencephaly; Holoprosencephaly 2

Paulussen, A.D., et al. Eur. J. Hum. Genet. 18(9):999-1005(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Hehr, U., et al. Hum. Genet. 127(5):555-561(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Mikkola, I., et al. J. Biol. Chem. 276(6):4109-4118(2001)

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