Homeobox protein SIX3; Sine oculis homeobox homolog 3

For Research Use Only. Not for use in diagnostic procedures.

Synthetic

>85%

Lyophilized powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Small volumes of SIX3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The peptide is used to block Anti-SIX3 Antibody reactivity.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

35,487 Da

SIX homeobox 3

homeobox protein SIX3; sine oculis homeobox homolog 3

Homeobox protein SIX3

SIX3_HUMAN

This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]

SIX3: May be involved in visual system development. Defects in SIX3 are the cause of holoprosencephaly type 2 (HPE2). Holoprosencephaly (HPE) is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Belongs to the SIX/Sine oculis homeobox family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: nucleus

Molecular Function: protein binding; histone deacetylase binding; transcription coactivator activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; lens development in camera-type eye; negative regulation of Wnt receptor signaling pathway; epithelial cell maturation; cell proliferation in forebrain; neuroblast differentiation; proximal/distal axis specification; forebrain dorsal/ventral pattern formation; telencephalon regionalization; circadian behavior; regulation of cell proliferation; telencephalon development; negative regulation of neuron differentiation; eye development; visual perception; protein import into nucleus, translocation; pituitary gland development; forebrain anterior/posterior pattern formation; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent

Disease: Schizencephaly; Holoprosencephaly 2

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.