Full Product Name
Rabbit Polyclonal (IgG) to Human ACTG2
Product Synonym Names
Anti-ACTG2 Antibody (aa1-50) IHC-plus; ACTA3; Actin-like protein; ACTSG; ACTE; Actin; alpha cardiac; ACTL3; Alpha-actin 3; Alpha-actin-3; Smooth muscle gamma-actin; Gamma-2-actin; Smooth muscle gamma actin; Human ACTG2
Product Gene Name
anti-ACTG2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P63267
Species Reactivity
Human, Mouse, Rat
Specificity
Actin-gamma2 Antibody detects endogenous levels of total Actin-gamma2 protein.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic peptide from human Actin-gamma2 (aa1-50).
Immunogen
ACTG2 antibody was raised against synthetic peptide from human Actin-gamma2 (aa1-50).
Antigen Modification
aa1-50
Preparation and Storage
Store at -20 degree C for up to one year.
Other Notes
Small volumes of anti-ACTG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACTG2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ACTG2 antibody
ELISA (1:20000), IHC-P (5 ug/ml), WB (1:500 - 1:1000)
Immunohistochemistry (IHC) of anti-ACTG2 antibody
Anti-ACTG2 / Gamma-2 Actin antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunohistochemistry (IHC) of anti-ACTG2 antibody
Anti-ACTG2 / Gamma-2 Actin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western Blot (WB) of anti-ACTG2 antibody
Western blot of extracts from COLO205 cells, using Actin-gamma2 Antibody. The lane on the right is treated with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for ACTG2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001606.1
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NCBI GenBank Nucleotide #
NM_001615.3
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UniProt Primary Accession #
P63267
[Other Products]
UniProt Secondary Accession #
P12718; Q504R1; Q6FI22; B2R7E7; B4E315; D6W5H8; E9PG30[Other Products]
UniProt Related Accession #
P63267[Other Products]
Molecular Weight
37,083 Da
NCBI Official Full Name
actin, gamma-enteric smooth muscle isoform 1
NCBI Official Synonym Full Names
actin, gamma 2, smooth muscle, enteric
NCBI Official Symbol
ACTG2??[Similar Products]
NCBI Official Synonym Symbols
ACT; ACTE; VSCM; ACTA3; ACTL3; ACTSG
??[Similar Products]
NCBI Protein Information
actin, gamma-enteric smooth muscle; alpha-actin-3; actin-like protein
UniProt Protein Name
Actin, gamma-enteric smooth muscle
UniProt Synonym Protein Names
Alpha-actin-3; Gamma-2-actin; Smooth muscle gamma-actin
UniProt Gene Name
ACTG2??[Similar Products]
UniProt Synonym Gene Names
ACTA3; ACTL3; ACTSG??[Similar Products]
UniProt Entry Name
ACTH_HUMAN
NCBI Summary for ACTG2
Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]
UniProt Comments for ACTG2
ACTG2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Contractile
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: extracellular space; cytoskeleton; cytosol
Molecular Function: ATP binding
Biological Process: muscle contraction
Disease: Visceral Myopathy
Research Articles on ACTG2
1. ACTG2 encodes g2 enteric actin and is the first gene to be clearly associated with Megacystis-microcolon-intestinal hypoperistalsis syndrome, suggesting an important role for contractile proteins in enteric smooth muscle disease.
Precautions
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Disclaimer
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