Mouse Potassium voltage-gated channel subfamily A member 1 (KCNA1) ELISA kit; AEMK; EA1; HBK1; HUK1; KV1.1; MBK1; MGC126782; MGC138385; MK1; RBK1; potassium voltage-gated channel subfamily A member 1; voltage-gated potassium channel subunit Kv1.1; potassium voltage-gated channel; shaker-related subfamily; member 1 (episodic ataxia with myokymia)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of KCNA1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9325318 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) (KCNA1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNA1. The ELISA analytical biochemical technique of the MBS9325318 kit is based on KCNA1 antibody-KCNA1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNA1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNA1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

56,409 Da

potassium voltage-gated channel, shaker-related subfamily, member 1

potassium voltage-gated channel subfamily A member 1; MKI; megencephaly; brain potassium channel protein-1; voltage-gated potassium channel subunit Kv1.1; potassium voltage gated channel, shaker related subfamily, member 1

Potassium voltage-gated channel subfamily A member 1

KCNA1_MOUSE

Kv1.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1); also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1). Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Cellular Component: voltage-gated potassium channel complex; cell surface; integral to plasma membrane; endoplasmic reticulum; dendrite; paranode region of axon; integral to membrane; cytosol; presynaptic membrane; cell projection; membrane; cell soma; axon; apical plasma membrane; plasma membrane; synapse; nerve terminal; cytoplasmic vesicle; cell junction

Molecular Function: voltage-gated potassium channel activity; potassium channel activity; delayed rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity

Biological Process: startle response; regulation of muscle contraction; neuromuscular process; hippocampus development; generation of action potential; detection of mechanical stimulus involved in sensory perception of pain; regulation of membrane potential; transport; neuroblast proliferation; ion transport; brain development; transmembrane transport; protein homooligomerization; potassium ion transport; detection of mechanical stimulus involved in sensory perception of touch

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