For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 4; NC_005103.3 (226188851..226190596, complement). Location: 4q42

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Kcna1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Kcna1

56,379 Da[Similar Products]

potassium voltage-gated channel, shaker-related subfamily, member 1

potassium voltage-gated channel subfamily A member 1; IA; RBKI; RCK1; voltage-gated potassium channel subunit Kv1.1; potassium (K+) channel protein voltage dependent; potassium voltage gated channel shaker related subfamily member 1

Potassium voltage-gated channel subfamily A member 1

KCNA1_RAT

voltage-gated potassium channel; activation is delayed [RGD, Feb 2006]

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure: Heterotetramer of potassium channel proteins. Binds KCNAB2

By similarity. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with LGI1 within a complex containing LGI1, KCNA4 and KCNAB1. Ref.4 Ref.5 Ref.6

Subcellular location: Membrane; Multi-pass membrane protein.

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Post-translational modification: Palmitoylated on Cys-243; which may be required for membrane targeting

By similarity.

Sequence similarities: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily. [View classification]

RNA editing: Edited at position 400.Partially edited. RNA editing is at an average of 50% in the whole brain. Ref.3

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