For Research Use Only. Not for use in diagnostic procedures.

Cell Free Expression

Liquid containing glycerol

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Kcna1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Transmembrane Protein

This is a recombinant transmembrane protein expressed in a cell-free expression system.

56,409 Da

potassium voltage-gated channel, shaker-related subfamily, member 1

potassium voltage-gated channel subfamily A member 1

Potassium voltage-gated channel subfamily A member 1

KCNA1_MOUSE

Kv1.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1); also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1). Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium

Cellular Component: apical plasma membrane; axon; cell junction; cell projection; cell soma; cell surface; cytoplasmic vesicle; cytosol; dendrite; endoplasmic reticulum; integral to membrane; integral to plasma membrane; membrane; nerve terminal; paranode region of axon; plasma membrane; presynaptic membrane; synapse; voltage-gated potassium channel complex

Molecular Function: delayed rectifier potassium channel activity; ion channel activity; potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity

Biological Process: brain development; detection of mechanical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of touch; generation of action potential; hippocampus development; ion transport; neuroblast proliferation; neuromuscular process; potassium ion transport; protein homooligomerization; regulation of membrane potential; regulation of muscle contraction; startle response; transmembrane transport; transport

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