Recombinant Potassium voltage-gated channel subfamily A member 1 (Kcna1); Potassium voltage-gated channel subfamily A member 1; MBK1 MKI Voltage-gated potassium channel subunit Kv1.1

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 6; NC_000072.6 (126636463..126645801, complement). Location: 6 F1-F3; 6 61.57 cM

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Kcna1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

56,409 Da[Similar Products]

potassium voltage-gated channel, shaker-related subfamily, member 1

potassium voltage-gated channel subfamily A member 1; MKI; megencephaly; brain potassium channel protein-1; voltage-gated potassium channel subunit Kv1.1; potassium voltage gated channel, shaker related subfamily, member 1

Potassium voltage-gated channel subfamily A member 1

KCNA1_MOUSE

Kv1.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1); also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1). Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Cellular Component: voltage-gated potassium channel complex; cell surface; endoplasmic reticulum; integral to plasma membrane; dendrite; paranode region of axon; integral to membrane; cytosol; presynaptic membrane; cell projection; cell soma; membrane; axon; apical plasma membrane; plasma membrane; synapse; cytoplasmic vesicle; nerve terminal; cell junction

Molecular Function: voltage-gated potassium channel activity; potassium channel activity; delayed rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity

Biological Process: startle response; regulation of muscle contraction; neuromuscular process; hippocampus development; generation of action potential; detection of mechanical stimulus involved in sensory perception of pain; regulation of membrane potential; transport; neuroblast proliferation; ion transport; brain development; transmembrane transport; potassium ion transport; detection of mechanical stimulus involved in sensory perception of touch; protein homooligomerization

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