Human GDP-fucose transporter 1 (SLC35C1) ELISA kit; FLJ11320; FLJ14841; FUCT1; GDP-fucose transporter 1; solute carrier family 35; member C1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SLC35C1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9321756 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the solute carrier family 35, member C1 (SLC35C1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SLC35C1. The ELISA analytical biochemical technique of the MBS9321756 kit is based on SLC35C1 antibody-SLC35C1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SLC35C1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SLC35C1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

39,809 Da

solute carrier family 35 (GDP-fucose transporter), member C1

GDP-fucose transporter 1; solute carrier family 35, member C1

GDP-fucose transporter 1

FUCT1??[Similar Products]

FUCT1_HUMAN

This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

SLC35C1: Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Defects in SLC35C1 are the cause of congenital disorder of glycosylation type 2C (CDG2C); also known as leukocyte adhesion deficiency type II (LAD2). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. The clinical features of CDG2C include mental retardation, short stature, facial stigmata, and recurrent bacterial peripheral infections with persistently elevated peripheral leukocytes. Biochemically, CDG2C is characterized by a lack of fucosylated glycoconjugates, including selectin ligands. Belongs to the TPT transporter family. SLC35C subfamily.

Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: Golgi membrane; Golgi apparatus; integral to membrane

Biological Process: carbohydrate transport; lipid glycosylation; negative regulation of Notch signaling pathway; transmembrane transport

Disease: Congenital Disorder Of Glycosylation, Type Iic

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