Full Product Name
ADH4 Antibody
Product Synonym Names
ADH-2
Product Gene Name
anti-ADH4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08319
Specificity
The antibody detects endogenous levels of total ADH4 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
0.9 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to residues near the C terminal of human alcohol dehydrogenase 4 (class II), pi polypeptide
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ADH4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ADH4 antibody
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
Product Categories/Family for anti-ADH4 antibody
Total protein Ab
Applications Tested/Suitable for anti-ADH4 antibody
Immunohistochemistry (IHC)
Application Notes for anti-ADH4 antibody
Immunohistochemistry: 1:25-1:100
Immunohistochemistry (IHC) of anti-ADH4 antibody
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/25.
Immunohistochemistry (IHC) of anti-ADH4 antibody
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/25.
NCBI/Uniprot data below describe general gene information for ADH4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000661.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000670.4
[Other Products]
UniProt Primary Accession #
P08319
[Other Products]
UniProt Secondary Accession #
Q8TCD7; A8K470; B4DIE7; C9J4A9[Other Products]
UniProt Related Accession #
P08319[Other Products]
Molecular Weight
42,607 Da
NCBI Official Full Name
alcohol dehydrogenase 4 isoform 2
NCBI Official Synonym Full Names
alcohol dehydrogenase 4 (class II), pi polypeptide
NCBI Official Symbol
ADH4??[Similar Products]
NCBI Official Synonym Symbols
ADH-2; HEL-S-4
??[Similar Products]
NCBI Protein Information
alcohol dehydrogenase 4
UniProt Protein Name
Alcohol dehydrogenase 4
UniProt Synonym Protein Names
Alcohol dehydrogenase class II pi chain
Protein Family
Alcohol dehydrogenase
UniProt Gene Name
ADH4??[Similar Products]
UniProt Entry Name
ADH4_HUMAN
NCBI Summary for ADH4
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
UniProt Comments for ADH4
ADH4: class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - retinol; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.1.1.1
Chromosomal Location of Human Ortholog: 4q22
Cellular Component: cytosol
Molecular Function: zinc ion binding; NADPH:quinone reductase activity; alcohol dehydrogenase activity; all-trans retinal binding; alcohol dehydrogenase activity, zinc-dependent; ethanol binding; aldehyde reductase activity; NAD binding; benzaldehyde dehydrogenase activity; retinol binding; retinol dehydrogenase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process: retinol metabolic process; xenobiotic metabolic process; alcohol metabolic process; alcohol catabolic process; aldehyde metabolic process; retinoid metabolic process; ethanol oxidation
Research Articles on ADH4
1. This study confirmed the genetic heterogeneity of cluster headache, suggesting that mutations in the ADH4 gene might be related to cluster headache in a subset of cases.
Precautions
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Disclaimer
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