For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity purified

Liquid

100ug/100ul (lot specific)

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Small volumes of anti-Mre11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

ELISA: 1:20,000~80,000
Western blotting: 1:500~1,000
Immunohistochemistry: 1:100~500

80,122 Da

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

double-strand break repair protein MRE11A; MRE11 homolog 1; MRE11 homolog A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A

Double-strand break repair protein MRE11A

MRE11_RAT

may play a role in regulation of cardiomyocyte proliferation [RGD, Feb 2006]

MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: DNA-binding; Deoxyribonuclease; DNA repair, damage; Cell cycle regulation

Cellular Component: nucleoplasm; chromosome, telomeric region; Mre11 complex; condensed nuclear chromosome; perinuclear region of cytoplasm; nuclear chromatin; nucleus

Molecular Function: protein C-terminus binding; ATP-dependent DNA helicase activity; protein binding; DNA binding; manganese ion binding; endonuclease activity; exonuclease activity; 3'-5' exonuclease activity

Biological Process: negative regulation of virion penetration into host cell; heart development; sister chromatid cohesion; positive regulation of kinase activity; negative regulation of DNA endoreduplication; chromosome organization and biogenesis; positive regulation of protein amino acid autophosphorylation; DNA duplex unwinding; cell proliferation; meiotic cell cycle; nucleotide-excision repair; intra-S DNA damage checkpoint; base-excision repair; mitotic cell cycle G2/M transition DNA damage checkpoint; double-strand break repair; synapsis; telomere maintenance; response to DNA damage stimulus

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