MRE11 antibody

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2b kappa

44B12

Mouse

Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles.

Small volumes of anti-MRE11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Cell Biology

Western Blot (WB)

WB: 1:2000

80,122 Da

MRE11 homolog A, double strand break repair nuclease

double-strand break repair protein MRE11; double-strand break repair protein MRE11A

Double-strand break repair protein MRE11

Mre11a; MRE11 homolog 1; MRE11 homolog A??[Similar Products]

may play a role in regulation of cardiomyocyte proliferation [RGD, Feb 2006]

MRE11A: a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms.

Protein type: Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease

Chromosomal Location of Human Ortholog: 8q12

Cellular Component: chromosome, telomeric region; condensed nuclear chromosome; Mre11 complex; nuclear chromatin; nuclear chromosome, telomeric region; nucleoplasm; nucleus; perinuclear region of cytoplasm; PML body

Molecular Function: 3'-5' exonuclease activity; ATP-dependent DNA helicase activity; DNA binding; endodeoxyribonuclease activity; protein binding; protein C-terminus binding; single-stranded DNA specific endodeoxyribonuclease activity

Biological Process: cell proliferation; chromosome organization and biogenesis; DNA duplex unwinding; double-strand break repair; double-strand break repair via nonhomologous end joining; heart development; intra-S DNA damage checkpoint; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of apoptosis; negative regulation of DNA endoreduplication; negative regulation of virion penetration into host cell; positive regulation of kinase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of telomere maintenance; response to DNA damage stimulus; sister chromatid cohesion; synapsis; telomeric 3' overhang formation

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