For Research Use Only. Not for use in diagnostic procedures.

Rabbit

1.0mg/ml (lot specific)

Small volumes of anti-PEX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB)

WB: 1:500-1:2000

105,999 Da

peroxisomal biogenesis factor 1

peroxisome biogenesis factor 1

Peroxisome biogenesis factor 1

This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

PEX1: Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Belongs to the AAA ATPase family. Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6.

Protein type: Hydrolase

Chromosomal Location of Human Ortholog: 7q21.2

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; peroxisomal membrane; peroxisome

Molecular Function: ATP binding; ATPase activity, coupled; protein binding; protein C-terminus binding; protein complex binding

Biological Process: microtubule-based peroxisome localization; peroxisome organization and biogenesis; protein import into peroxisome matrix; protein targeting to peroxisome

Disease: Heimler Syndrome 1; Peroxisome Biogenesis Disorder 1a (zellweger); Peroxisome Biogenesis Disorder 1b

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