Product Name
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (Mgat4a), Recombinant Protein
Full Product Name
Recombinant Mouse Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (Mgat4a), partial
Product Gene Name
Mgat4a recombinant protein
[Similar Products]
Product Synonym Gene Name
Mgat4a[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MRLRNGTVAT ALVFVTSFLT LSWYTTWQNG KEKLIAYQRE FLALKERLRV AEHRISQRSS ELNTIVQQFR RAGAETNGSK TALSTISDNT IKLLKELTSK KSLRVPSIYY HLPHLLQNER SLQPAVQIGS GRTGVSIVMG IPTVKREVKS YLVETLHSLI DNLYPEEKLD CVIVVFIGET DLDYVHSVVA NLEKEFSREI SSGLLEIISP PESYYPDLTN LKETFGDSKE RVRWRTKQNL DYCFLMMYAQ EKGIYYIQLE DDIIVKQNYF NTIKNFALQL SSEEWMILEF SQLGFIGKMF QAPDLALVVE FILMFYKEKP IDWLLDHILW VKVCNPEKDA KHCDRQKANL RIRFRPSLFQ HVGLHSSLSG KIQKLTDKDY MKPLLLKVHV NPPAEVSTSL KVYQGHTLEK TYMGEDFFWA ITPTAGDYIL FKFDKPVNVE SYLFHSGNQE HPGDILLNTT VDVLPLKSDS LEISKETKDK RLEDGYFRIG KFEYGVAEGI VDPGLNPISA FRLSVIQNSA VWAILNEIHI KKVTS
3D Structure
ModBase 3D Structure for Q812G0
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Mgat4a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Mgat4a recombinant protein
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
NCBI/Uniprot data below describe general gene information for Mgat4a. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001277730.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001290801.1
[Other Products]
UniProt Primary Accession #
Q812G0
[Other Products]
UniProt Secondary Accession #
Q3TQT1; Q80UI0[Other Products]
UniProt Related Accession #
Q812G0[Other Products]
Molecular Weight
60,590 Da
NCBI Official Full Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2
NCBI Official Synonym Full Names
mannoside acetylglucosaminyltransferase 4, isoenzyme A
NCBI Official Symbol
Mgat4a??[Similar Products]
NCBI Official Synonym Symbols
GnT-IVa; glcNAc-T-IVa; 9530018I07Rik
??[Similar Products]
NCBI Protein Information
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
UniProt Protein Name
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
UniProt Synonym Protein Names
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; GlcNAc-T IVa; GnT-IVa; N-acetylglucosaminyltransferase IVa
Protein Family
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
UniProt Gene Name
Mgat4a??[Similar Products]
UniProt Synonym Gene Names
GlcNAc-T IVa; GnT-IVa; N-acetylglucosaminyltransferase IVa??[Similar Products]
UniProt Comments for Mgat4a
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.
Research Articles on Mgat4a
1. our results suggest that let-7c may inhibit the metastatic ability of Hca-F cells, at least partially, via repressing Mgat4a activity.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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