Keratin type I cytoskeletal 17; 39.1; Cytokeratin-17; CK-17; Keratin-17; K17

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

Mouse

Recognizes endogenous levels of Cytokeratin 17 protein.

Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Mouse monoclonal to Cytokeratin 17

Western Blot (WB), Immunoprecipitation (IP)

Western Blot: (1/1000 - 1/2000); Immunoprecipitation: (1/50 - 1/200)

Western blot analysis of Cytokeratin 17 expression in Hela (A), MCF7 (B), 293T (C) whole cell lysates.

Immunoprecipitation of Cytokeratin 17 from 0.5mg Hela whole cell extract lysate, using anti-Cytokeratin 17 Antibody.

48,106 Da

keratin 17

keratin, type I cytoskeletal 17

Keratin, type I cytoskeletal 17

CK-17; K17??[Similar Products]

K1C17_HUMAN

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; intermediate filament

Molecular Function: MHC class II protein binding; MHC class II receptor activity; protein binding; structural constituent of cytoskeleton

Biological Process: epidermis development; hair follicle morphogenesis; intermediate filament organization; keratinization; positive regulation of cell growth; positive regulation of hair follicle development; positive regulation of translation; signal transduction

Disease: Pachyonychia Congenita 2; Steatocystoma Multiplex

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