Product Name
Cytokeratin 17 (KRT17), Polyclonal Antibody
Full Product Name
Rabbit anti Cytokeratin 17
Product Synonym Names
Cytokeratin 17 Antibody
Product Gene Name
anti-KRT17 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q04695
Species Reactivity
Human, Rat, Mouse (Expected from Sequence)
Purity/Purification
Purified whole serum by affinity chromatography.
Form/Format
Liquid in phosphate buffered saline with 0.02% sodium azide, 50% glycerol.
Immunogen
Recombinant human cytokeratin 17
Preperation
Antiserum to cytokeratin 17 was raised by repeated immunization of rabbits with highly purified antigen.
Preparation and Storage
Store at -20 degree C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch
Other Notes
Small volumes of anti-KRT17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KRT17 antibody
Rabbit anti cytokeratin 17 antibody recognizes human cytokeratin 17, also known as keratin-17, keratin type I cytoskeletal 17, KRT17 or CK-17. Cytokeratin 17 is a type I cytokeratin expressed in epithelial appendages such as hair follicles. Cytokeratin 17 is a potential prognostic biomarker in several forms of cancer.
Applications Tested/Suitable for anti-KRT17 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-KRT17 antibody
IHC-Paraffin: 1:50-1:200
WB: 1:500-1:2000
Western Blot (WB) of anti-KRT17 antibody
Western blot analysis of cell lysates using Rabbit anti cytokeratin 17 antibody
Immunohistochemistry (IHC) of anti-KRT17 antibody
Immunohistochemistry of paraffin-embedded rat kidney using Rabbit anti cytokeratin 17 antibody at a dilution of 1/200
NCBI/Uniprot data below describe general gene information for KRT17. It may not necessarily be applicable to this product.
NCBI Accession #
Q04695.2
[Other Products]
UniProt Primary Accession #
Q04695
[Other Products]
UniProt Secondary Accession #
Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2[Other Products]
UniProt Related Accession #
Q04695[Other Products]
Molecular Weight
48,106 Da
NCBI Official Full Name
Keratin, type I cytoskeletal 17
NCBI Official Synonym Full Names
keratin 17
NCBI Official Symbol
KRT17??[Similar Products]
NCBI Official Synonym Symbols
PC; K17; PC2; 39.1; CK-17; PCHC1
??[Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 17
UniProt Protein Name
Keratin, type I cytoskeletal 17
UniProt Synonym Protein Names
39.1; Cytokeratin-17; CK-17; Keratin-17; K17
UniProt Gene Name
KRT17??[Similar Products]
UniProt Synonym Gene Names
CK-17; K17??[Similar Products]
NCBI Summary for KRT17
This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]
UniProt Comments for KRT17
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.
Research Articles on KRT17
1. The findings suggest that CK17, although not specific for differentiated vulvar intraepithelial neoplasia (dVIN), when combined with histologic findings, Ki-67, and p53 immunohistochemistry, can be a marker of vulvar dysplasia and serve as an adjunct in the diagnosis of dVIN.
Precautions
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Disclaimer
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