Full Product Name
SOX2 Antibody
Product Synonym Names
Mouse monoclonal IgG to SOX2
Product Gene Name
anti-SOX2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48431
Purity/Purification
Protein G-Sepharose affinity purified.
Immunogen
Recombinant fragment of human SOX2 (N-terminus).
Preservative
0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
Cellular Localization
Nucleus
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-SOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SOX2 antibody
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate.
Applications Tested/Suitable for anti-SOX2 antibody
ELSIA (EIA), Western Blot (WB)
Application Notes for anti-SOX2 antibody
ELISA: 1:5000-1:20000
WB: 1:100-1:2000
Testing Data of anti-SOX2 antibody
SOX2 antibody at 1/1000 dilution. Lane1: Mouse Embryonic Germ whole cell lysate 40ug/Lane. Lane2: F9 whole cell lysate 40ug/Lane. Predicted band size:34KDa. Observed band size:39KDa.
NCBI/Uniprot data below describe general gene information for SOX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003097.1
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NCBI GenBank Nucleotide #
NM_003106.2
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UniProt Primary Accession #
P48431
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UniProt Secondary Accession #
Q14537[Other Products]
UniProt Related Accession #
P48431[Other Products]
Molecular Weight
34,310 Da
NCBI Official Full Name
transcription factor SOX-2
NCBI Official Synonym Full Names
SRY-box 2
NCBI Official Symbol
SOX2??[Similar Products]
NCBI Official Synonym Symbols
ANOP3; MCOPS3
??[Similar Products]
NCBI Protein Information
transcription factor SOX-2
UniProt Protein Name
Transcription factor SOX-2
UniProt Gene Name
SOX2??[Similar Products]
NCBI Summary for SOX2
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
UniProt Comments for SOX2
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation ().
Research Articles on SOX2
1. Block the activation of the VRK1 promoter by Sox2.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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