SOX-2; SOX2; SRY-Box 2; ANOP3; MCOPS3; SRY (Sex Determining Region Y)-Box 2

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG1

AHC0234

Mouse

Human SOX-2

Protein A/G Affinity Purified

Liquid

100 ug/ 100 ul (lot specific)

Stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at -20 degree C or below.
Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Small volumes of anti-SOX-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

SRY (sex determining region Y)-Box 2 or SOX-2, is a transcription factor that regulates the pluripotency of undifferentiated embryonic stem cells, and regulates gene expression in the stomach. It is a valuable tool to study stage I lung adenocarcinomas as it has been indicated to be a predictor of poor prognosis. It may be used to detect squamous cell carcinomas of the lung and gastrointestinal tract, and embryonal carcinoma.

Immunohistochemisty (IHC)

Suggested Dilution: 1:1000-1:3000

34,310 Da

SRY-box 2

transcription factor SOX-2

Transcription factor SOX-2

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation ().

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