Product Synonym Names
SOX 2
Product Gene Name
anti-SOX-2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48431
Positive Control
Lung Squamous Carcinoma
Other Notes
Small volumes of anti-SOX-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SOX-2 antibody
SOX 2, also known as SRY (sex determining region Y)-box 2, is a transcription factor that acts to regulate pluripotency of undifferentiated embryonic stem cells, and to regulate gene expression in the stomach. This diagnostic grade SOX 2 IVD antibody is used to detect melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and teratoma of the central nervous system. SOX 2 has been reported as a predictor of poor outcome in stage I lung adenocarcinomas. Anti-SOX 2 is also used to recognize squamous cell carcinomas of the lung and gastrointestinal tract, and may be useful for detecting embryonal carcinoma.
Application Notes for anti-SOX-2 antibody
The recommended working dilution range is 1:100-1:200
Immunohistochemistry (IHC) of anti-SOX-2 antibody
SOX 2 [IHC665] on Cervix
NCBI/Uniprot data below describe general gene information for SOX-2. It may not necessarily be applicable to this product.
NCBI Accession #
CAA83435.1
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UniProt Primary Accession #
P48431
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UniProt Secondary Accession #
Q14537[Other Products]
UniProt Related Accession #
P48431[Other Products]
Molecular Weight
34,310 Da
NCBI Official Full Name
sox-2, partial
NCBI Official Synonym Full Names
SRY-box 2
NCBI Official Symbol
SOX2??[Similar Products]
NCBI Official Synonym Symbols
ANOP3; MCOPS3
??[Similar Products]
NCBI Protein Information
transcription factor SOX-2
UniProt Protein Name
Transcription factor SOX-2
Protein Family
Transcription factor
UniProt Gene Name
SOX2??[Similar Products]
NCBI Summary for SOX-2
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
UniProt Comments for SOX-2
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation ().
Product References and Citations for anti-SOX-2 antibody
1. Rizzino A, et al. Wiley Interdiscip Rev Syst Biol Med. 2009; 1:228-36.
2. Laga AC, et al. Am J Pathol. 2010; 176:903-13.
3. Ji J, et al. Hum Pathol. 2010; 41:1438-47.
4. Rodriguez-Pinilla SM, et al. Mod Pathol. 2007; 20:474-81.
5. Long KB, et al. Hum Pathol. 2009; 40:1768-73.
6. Sholl LM, et al. Appl Immunohistochem Mol Morphol. 2010; 18:55-61.
7. Tsuta K, et al. J Thorac Oncol. 2011; 6:1190-9.
8. Gopalan A, et al. Mod Pathol. 2009; 22:1066-74.
Research Articles on SOX-2
1. Tumor tissue Sox2 expression was not positively correlated with histologic grade, pathological tumor size and prognosis in surgical patients with triple-negative breast cancer.
Precautions
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