Product Name
Prekallikrein (KLKB1), Monoclonal Antibody
Full Product Name
Anti Mouse Prekallikrein MAb Sample Pack
Product Gene Name
anti-KLKB1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P26262
Purity/Purification
IgG fraction
Form/Format
Frozen Liquid-0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
Source
Hybridoma Cell Culture
Antigen
Recombinant full length wild-type mouse protein (Glycosylated).
Extinction Coefficient
1.36
Epitope
Recognizes Mouse Prekallikrein
Preparation and Storage
Store at -70 degree C.
Other Notes
Small volumes of anti-KLKB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KLKB1 antibody
Anti Mouse Prekallikrein MAb Sample Pack
20 ug of each of PK3A10, PK5G7, PK7G2, PK11H4, PK14E3, and PK13G5.
Product Categories/Family for anti-KLKB1 antibody
Monoclonal Antibodies to Mouse Prekallikrein; Anti Mouse Targets
Applications Tested/Suitable for anti-KLKB1 antibody
Capture, ELISA (EIA), Inhibitory Antibody, Western Blot (WB)
NCBI/Uniprot data below describe general gene information for KLKB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032481.2
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NCBI GenBank Nucleotide #
NM_008455.3
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UniProt Primary Accession #
P26262
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UniProt Secondary Accession #
Q8R0P5[Other Products]
UniProt Related Accession #
P26262[Other Products]
Molecular Weight
Molecular Weight: 160,000
Target Molecular Weight: 81,000
NCBI Official Full Name
plasma kallikrein preproprotein
NCBI Official Synonym Full Names
kallikrein B, plasma 1
NCBI Official Symbol
Klkb1??[Similar Products]
NCBI Official Synonym Symbols
APS; PSA; Kal3; Klk3; Kal-3
??[Similar Products]
NCBI Protein Information
plasma kallikrein
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikrein
Protein Family
Plasma kallikrein
UniProt Gene Name
Klkb1??[Similar Products]
UniProt Synonym Gene Names
Klk3; Pk??[Similar Products]
NCBI Summary for KLKB1
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric enzyme comprised of heavy and light chains. A complete deletion of the encoded protein prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. [provided by RefSeq, May 2016]
UniProt Comments for KLKB1
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Research Articles on KLKB1
1. Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
