Product Name
Prekallikrein (KLKB1), Plasma
Full Product Name
Mouse Prekallikrein Genetically Deficient Plasma, Sodium Citrate
Product Gene Name
KLKB1 plasma
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P26262
Purity/Purification
Plasma
Form/Format
Frozen Liquid
Preparation and Storage
Store at -70 degree C.
Other Notes
Small volumes of KLKB1 plasma vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
KLKB1 plasma
This plasma is an ideal negative control for ELISA based assays and other experiments involving prekallikrein, also known as plasma kallikrein B. Collected from homozygous prekallikrein knockout mice, anticoagulated with sodium citrate and flash frozen. Collected from male mice. Female mouse plasma is also available. Freshly collected prekallikrein knockout mouse organs are also available, please click here to inquire. The clotting time of this plasma is greatly extended compared to normal wild type plasma.
Product Categories/Family for KLKB1 plasma
Prekallikrein Deficient Plasma; Depleted Plasma
NCBI/Uniprot data below describe general gene information for KLKB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032481.2
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NCBI GenBank Nucleotide #
NM_008455.3
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UniProt Primary Accession #
P26262
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UniProt Secondary Accession #
Q8R0P5[Other Products]
UniProt Related Accession #
P26262[Other Products]
Molecular Weight
71,383 Da
NCBI Official Full Name
plasma kallikrein preproprotein
NCBI Official Synonym Full Names
kallikrein B, plasma 1
NCBI Official Symbol
Klkb1??[Similar Products]
NCBI Official Synonym Symbols
APS; PSA; Kal3; Klk3; Kal-3
??[Similar Products]
NCBI Protein Information
plasma kallikrein
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikrein
Protein Family
Plasma kallikrein
UniProt Gene Name
Klkb1??[Similar Products]
UniProt Synonym Gene Names
Klk3; Pk??[Similar Products]
NCBI Summary for KLKB1
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric enzyme comprised of heavy and light chains. A complete deletion of the encoded protein prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. [provided by RefSeq, May 2016]
UniProt Comments for KLKB1
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Research Articles on KLKB1
1. Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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