Product Name
DEPD5 (DEPDC5), Blocking Peptide
Full Product Name
DEPD5 Antibody (C-term) Blocking peptide
Product Synonym Names
DEP domain-containing protein 5; DEPDC5; KIAA0645
Product Gene Name
DEPDC5 blocking peptide
[Similar Products]
Product Synonym Gene Name
KIAA0645[Similar Products]
Antibody/Peptide Pairs
DEPD5 peptide (MBS9218794) is used for blocking the activity of DEPD5 antibody (MBS9207358)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75140
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm, cytosol. Cytoplasm, perinuclear region
Tissue Location
Expressed in developing and ***** brain.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of DEPDC5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
DEPDC5 blocking peptide
As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC- containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.
NCBI/Uniprot data below describe general gene information for DEPDC5. It may not necessarily be applicable to this product.
NCBI Accession #
O75140.2
[Other Products]
UniProt Primary Accession #
O75140
[Other Products]
UniProt Secondary Accession #
Q5K3V5; Q5THY9; Q5THZ0; Q5THZ1; Q5THZ3; Q68DR1; Q6MZX3; A6H8V6; A8MPX9; B4DH93; B9EGN9[Other Products]
UniProt Related Accession #
O75140[Other Products]
Molecular Weight
177,910 Da
NCBI Official Full Name
DEP domain-containing protein 5
NCBI Official Synonym Full Names
DEP domain containing 5
NCBI Official Symbol
DEPDC5??[Similar Products]
NCBI Official Synonym Symbols
DEP.5; FFEVF
??[Similar Products]
NCBI Protein Information
DEP domain-containing protein 5
UniProt Protein Name
DEP domain-containing protein 5
Protein Family
DEP domain-containing protein
UniProt Gene Name
DEPDC5??[Similar Products]
UniProt Synonym Gene Names
KIAA0645??[Similar Products]
UniProt Entry Name
DEPD5_HUMAN
NCBI Summary for DEPDC5
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for DEPDC5
DEPDC5: Belongs to the IML1 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: cytosol; lysosomal membrane; lysosome; perinuclear region of cytoplasm
Molecular Function: GTPase activator activity; protein complex binding
Biological Process: cellular response to amino acid starvation; negative regulation of TOR signaling pathway
Disease: Epilepsy, Familial Focal, With Variable Foci
Research Articles on DEPDC5
1. DEPDC5 variants increase fibrosis progression in European subjects with chronic HCV infection. Our findings suggest that DEPDC5 down-regulation may contribute to HCV-related fibrosis by increasing MMP2 synthesis through the beta-catenin pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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