Product Name
Sex Determining Region Y Box Protein 2 (SOX2), Monoclonal Antibody
Full Product Name
HRP-Linked Monoclonal Antibody to Sex Determining Region Y Box Protein 2 (SOX2)
Product Synonym Names
ANOP3; MCOPS3; SRY-Box 2; Transcription factor SOX-2
Product Gene Name
anti-SOX2 antibody
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Matching Pairs
Antibody: Sex Determining Region Y Box Protein 2 (SOX2) Clone #D3 (MBS2106887)
Antigen: Sex Determining Region Y Box Protein 2 (MBS2031007)
Matching Pairs
Unconjugated Antibody: Sex Determining Region Y Box Protein 2 (SOX2) Clone #D3 (MBS2111130)
HRP Conjugated Antibody: Sex Determining Region Y Box Protein 2 (SOX2) Clone #D3 (MBS2106887)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
His105~Met 317
3D Structure
ModBase 3D Structure for P48431
Specificity
The antibody is a mouse monoclonal antibody raised against SOX2. It has been selected for its ability to recognize SOX2 in immunohistochemical staining and western blotting.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
500ug/ml (lot specific)
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-SOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SOX2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
NCBI/Uniprot data below describe general gene information for SOX2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003097.1
[Other Products]
NCBI GenBank Nucleotide #
NM_003106.4
[Other Products]
UniProt Primary Accession #
P48431
[Other Products]
UniProt Related Accession #
P48431[Other Products]
NCBI Official Full Name
transcription factor SOX-2
NCBI Official Synonym Full Names
SRY-box 2
NCBI Official Symbol
SOX2??[Similar Products]
NCBI Official Synonym Symbols
ANOP3; MCOPS3
??[Similar Products]
NCBI Protein Information
transcription factor SOX-2
UniProt Protein Name
Transcription factor SOX-2
UniProt Gene Name
SOX2??[Similar Products]
UniProt Entry Name
SOX2_HUMAN
NCBI Summary for SOX2
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
Research Articles on SOX2
1. BRACHYURY and SOX2 synergistically promote cancer stemness in oral cancer cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
