Product Name
Ectodysplasin-A (EDA), Recombinant Protein
Full Product Name
Recombinant Bovine Ectodysplasin-A (EDA), partial
Product Gene Name
EDA recombinant protein
[Similar Products]
Product Synonym Gene Name
EDA[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
63-391
Sequence
ELRSELRR ERGAESRFSG PGTPGTSGTL SSPGGLDPNG PITRHFGQRS PQQQPLEPGE TTLPPDSQDG HQMALVNFFI PKEKSYSEEE SRRVRRNKRS KSSEGADGPV KNKKKGKKAG PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI AVKMVHADIS INMSKHTTFF GAIRLGEAPA S
3D Structure
ModBase 3D Structure for Q9BEG5
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of EDA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
EDA recombinant protein
This protein is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for EDA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001075212.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001081743.2
[Other Products]
UniProt Primary Accession #
Q9BEG5
[Other Products]
UniProt Secondary Accession #
Q9BEG6[Other Products]
UniProt Related Accession #
Q9BEG5[Other Products]
Molecular Weight
41,339 Da
NCBI Official Full Name
ectodysplasin-A
NCBI Official Synonym Full Names
ectodysplasin A
NCBI Official Symbol
EDA??[Similar Products]
NCBI Official Synonym Symbols
ED1
??[Similar Products]
NCBI Protein Information
ectodysplasin-A
UniProt Protein Name
Ectodysplasin-A
UniProt Synonym Protein Names
Ectodermal dysplasia protein; Ectodysplasin-1
Protein Family
Ectodysplasin
UniProt Gene Name
EDA??[Similar Products]
UniProt Synonym Gene Names
ED1??[Similar Products]
UniProt Comments for EDA
Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform A1 binds only to the receptor EDAR, while isoform A2 binds exclusively to the receptor EDA2R. May also play a role in cell adhesion.
Research Articles on EDA
1. Authors identifya mutation, never described before, that changes the regulation of alternative splicing in the EDA gene and causes ectodermal dysplasia in cattle.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
