Ectodysplasin-A; EDA protein homolog; Tabby protein; Eda; Ed1; Ta

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of Eda elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9427972 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Ectodysplasin-A (Eda) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Eda. The ELISA analytical biochemical technique of the MBS9427972 kit is based on Eda antibody-Eda antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Eda antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Eda. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

39,988 Da

ectodysplasin-A

ectodysplasin-A

Ectodysplasin-A

Ed1; Ta??[Similar Products]

EDA: Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1); also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias. Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1). A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Belongs to the tumor necrosis factor family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: X C3|X 43.59 cM

Cellular Component: apical part of cell; endoplasmic reticulum membrane; integral to plasma membrane

Biological Process: cell-matrix adhesion; gene expression; hair follicle development; odontogenesis of dentine-containing teeth; pigmentation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB import into nucleus; skin development

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