Product Name
Ectodysplasin A (EDA), Polyclonal Antibody
Full Product Name
Ectodysplasin A antibody
Product Synonym Names
Polyclonal Ectodysplasin A; Anti-Ectodysplasin A; ED1-A1; ED1-A2; XHED; EDA2; ED1; XLHED; HED; EDA1; EDA
Product Gene Name
anti-EDA antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Ectodysplasin A antibody was purified by affinity chromatography
Form/Format
Supplied in lyophilized form
Biological Significance
EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. It belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Immunogen
Ectodysplasin A antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence in the middle region of human ED1, identical to the related Rabbit and rat sequence as the immunogen
Preparation and Storage
Store at 4 degree C for short term storage. For long term storage aliquot and store at -20 degree C, avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-EDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EDA antibody
Affinity purified Rabbit polyclonal Ectodysplasin A antibody
Product Categories/Family for anti-EDA antibody
Signal Transduction; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-EDA antibody
Western Blot (WB)
Application Notes for anti-EDA antibody
Optimal conditions to be determined by the end user
Western Blot (WB) of anti-EDA antibody
Western Blot using SW620 Cell Lysate
NCBI/Uniprot data below describe general gene information for EDA. It may not necessarily be applicable to this product.
NCBI Accession #
AAI44052.1
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UniProt Secondary Accession #
O75910; Q5JS00; Q5JUM7; Q9UP77; Q9Y6L0; Q9Y6L1; Q9Y6L2; A0AUZ2; A2A337; B7ZLU2; B7ZLU4[Other Products]
UniProt Related Accession #
Q92838[Other Products]
Molecular Weight
40,750 Da[Similar Products]
NCBI Official Full Name
Ectodysplasin A
NCBI Official Synonym Full Names
ectodysplasin A
NCBI Official Symbol
EDA??[Similar Products]
NCBI Official Synonym Symbols
ED1; HED; EDA1; EDA2; HED1; ODT1; XHED; ECTD1; XLHED; ED1-A1; ED1-A2; EDA-A1; EDA-A2; STHAGX1
??[Similar Products]
NCBI Protein Information
ectodysplasin-A
UniProt Protein Name
Ectodysplasin-A
UniProt Synonym Protein Names
Ectodermal dysplasia protein; EDA protein
Protein Family
Ectodysplasin
UniProt Gene Name
EDA??[Similar Products]
UniProt Synonym Gene Names
ED1; EDA2; EDA protein??[Similar Products]
UniProt Entry Name
EDA_HUMAN
NCBI Summary for EDA
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for EDA
EDA: Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1); also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias. Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1). A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Belongs to the tumor necrosis factor family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq12-q13.1
Cellular Component: endoplasmic reticulum membrane; collagen; cytoskeleton; intracellular membrane-bound organelle; membrane; integral to plasma membrane; apical part of cell; plasma membrane; integral to membrane; extracellular region
Molecular Function: protein binding; tumor necrosis factor receptor binding; receptor binding
Biological Process: pigmentation; cell-matrix adhesion; ectoderm development; gene expression; positive regulation of NF-kappaB import into nucleus; immune response; cell differentiation; signal transduction; activation of NF-kappaB transcription factor; odontogenesis of dentine-containing teeth
Disease: Tooth Agenesis, Selective, X-linked, 1; Ectodermal Dysplasia 1, Hypohidrotic, X-linked
Research Articles on EDA
1. novel non-synonymous mutation in ectodysplasin A (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis
Precautions
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