Product Name
TPP1, cDNA Clone
Popular Item
Full Product Name
TPP1 cDNA Clone
Product Gene Name
TPP1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgggactcc aagcctgcct cctagggctc tttgccctca tcctctctgg caaatgcagt tacagcccgg agcccgacca gcggaggacg ctgcccccag gctgggtgtc cctgggccgt gcggaccctg aggaagagct gagtctcacc tttgccctga gacagcagaa tgtggaaaga ctctcggagc tggtgcaggc tgtgtcggat cccagctctc ctcaatacgg aaaatacctg accctagaga atgtggctga tctggtgagg ccatccccac tgaccctcca cacggtgcaa aaatggctct tggcagccgg agcccagaag tgccattctg tgatcacaca ggactttctg acttgctggc tgagcatccg acaagcagag ctgctgctcc ctggggctga gtttcatcac tatgtgggag gacctacgga aacccatgtt gtaaggtccc cacatcccta ccagcttcca caggccttgg ccccccatgt ggactttgtg gggggactgc accgttttcc cccaacatca tccctgaggc aacgtcctga gccgcaggtg acagggactg taggcctgca tctgggggta accccctctg tgatccgtaa gcgatacaac ttgacctcac aagacgtggg ctctggcacc agcaataaca gccaagcctg tgcccagttc ctggagcagt atttccatga ctcagacctg gctcagttca tgcgcctctt cggtggcaac tttgcacatc aggcatcagt agcccgtgtg gttggacaac agggccgggg ccgggccggg attgaggcca gtctagatgt gcagtacctg atgagtgctg gtgccaacat ctccacctgg gtctacagta gccctggccg gcatgaggga caggagccct tcctgcagtg gctcatgctg ctcagtaatg agtcagccct gccacatgtg catactgtga gctatggaga tgatgaggac tccctcagca gcgcctacat ccagcgggtc aacactgagc tcatgaaggc tgccgctcgg ggtctcaccc tgctcttcgc ctcaggtgac agtggggccg ggtgttggtc tgtctctgga agacacgagt tccgccctac cttccctgcc tccagcccct atgtcaccac agtgggaggc acatccttcc aggaaccttt cctcatcaca aatgaaattg ttgactatat cagtggtggt ggcttcagca atgtgttccc acggccttca taccaggagg aagctgtaac gaagttcctg agctctagcc cccacctgcc accatccagt tacttcaatg ccagtggccg tgcctaccca gatgtggctg cactttctga tggctactgg gtggtcagca acagagtgcc cattccatgg gtgtccggaa cctcggcctc tactccagtg tttgggggga tcctatcctt gatcaatgag cacaggatcc ttagtggccg cccccctctt ggctttctca acccaaggct ctaccagcag catggggcag gactctttga tgtaacccgt ggctgccatg agtcctgtct ggatgaagag gtagagggcc agggtttctg ctctggtcct ggctgggatc ctgtaacagg ctggggaaca cccaacttcc cagctttgct gaagactcta ctcaacccct ga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of TPP1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TPP1. It may not necessarily be applicable to this product.
NCBI Accession #
BC014863
[Other Products]
UniProt Secondary Accession #
Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37[Other Products]
UniProt Related Accession #
O14773[Other Products]
Molecular Weight
34,464 Da
NCBI Official Full Name
Homo sapiens tripeptidyl peptidase I, mRNA
NCBI Official Synonym Full Names
tripeptidyl peptidase 1
NCBI Official Symbol
TPP1??[Similar Products]
NCBI Official Synonym Symbols
CLN2; GIG1; LPIC; SCAR7; TPP-1
??[Similar Products]
NCBI Protein Information
tripeptidyl-peptidase 1
UniProt Protein Name
Tripeptidyl-peptidase 1
UniProt Synonym Protein Names
Cell growth-inhibiting gene 1 protein; Lysosomal pepstatin-insensitive protease; LPIC; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I; TPP-I
Protein Family
Tripeptidyl-peptidase
UniProt Gene Name
TPP1??[Similar Products]
UniProt Synonym Gene Names
CLN2; TPP-1; LPIC; TPP-I??[Similar Products]
UniProt Entry Name
TPP1_HUMAN
NCBI Summary for TPP1
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
UniProt Comments for TPP1
TPP1: Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. Defects in TPP1 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2). A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN2 consists of curvilinear profiles. Belongs to the peptidase S53 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Secreted, signal peptide; Secreted; Protease; EC 3.4.14.9
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: lysosomal lumen; lysosome
Molecular Function: endopeptidase activity; peptidase activity; peptide binding; protein binding; serine-type peptidase activity; tripeptidyl-peptidase activity
Biological Process: bone resorption; central nervous system development; epithelial cell differentiation; lipid metabolic process; lysosome organization and biogenesis; nervous system development; neuromuscular process controlling balance; peptide catabolic process; proteolysis
Disease: Ceroid Lipofuscinosis, Neuronal, 2
Research Articles on TPP1
1. The conservation between fission yeast Tpz1-Pot1 and human TPP1-POT1 interactions resulted in mapping a human melanoma-associated POT1 mutation (A532P) to the TPP1-POT1 interface.
Precautions
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Disclaimer
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