Product Name
Plasma Kallikrein (KLKB1), Polyclonal Antibody
Full Product Name
Cleaved-Plasma Kallikrein HC (R390) Polyclonal Antibody
Product Gene Name
anti-KLKB1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P03952
Other Notes
Small volumes of anti-KLKB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for KLKB1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000883.2
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NCBI GenBank Nucleotide #
NM_000892.4
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UniProt Primary Accession #
P03952
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UniProt Secondary Accession #
Q17RE8; Q17RE9; Q4W5C3; A6NH96; B2R8H9[Other Products]
UniProt Related Accession #
P03952[Other Products]
Molecular Weight
71,370 Da[Similar Products]
NCBI Official Full Name
plasma kallikrein isoform 1 preproprotein
NCBI Official Synonym Full Names
kallikrein B1
NCBI Official Symbol
KLKB1??[Similar Products]
NCBI Official Synonym Symbols
PKK; PPK; KLK3; PKKD
??[Similar Products]
NCBI Protein Information
plasma kallikrein
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikrein; PKK
Protein Family
Plasma kallikrein
UniProt Gene Name
KLKB1??[Similar Products]
UniProt Synonym Gene Names
KLK3; PKK??[Similar Products]
NCBI Summary for KLKB1
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
UniProt Comments for KLKB1
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Research Articles on KLKB1
1. High molecular weight kinin functions as a cofactor for PK activation in the presence of nucleic acids in a manner consistent with classic models of contact activation.
Precautions
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Disclaimer
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