Anti-KLKB1 / Plasma Kallikrein Antibody IHC-plus; KLKB1; Fletcher factor deficiency; Fletcher factor; Kininogenin; Plasma kallikrein; PKK deficiency; Plasma kallikrein heavy chain; PPK; Prekallikrein deficiency; Plasma kallikrein light chain; Plasma prekallikrein; Kallikrein 3; Human KLKB1; Plasma Kallikrein

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Sheep

Specific for PK as demonstrated by immunoelectrophoresis and ELISA.

Ammonium sulfate precipitation

10 mM HEPES, pH 7.4, 0.15 M sodium chloride, 50% glycerol.

1 mg/ml (lot specific)

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Small volumes of anti-KLKB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Subfamily:-Serine-S1">Family: Protease
Subfamily: Serine S1

Immunohistochemistry (IHC - Paraffin), ELISA (EIA), Immunoelectrophoresis

ELISA, IE, IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Anti-KLKB1 antibody IHC of human small intestine, vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

71,370 Da

kallikrein B, plasma (Fletcher factor) 1

plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain

Plasma kallikrein

KLK3??[Similar Products]

KLKB1_HUMAN

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq, Jul 2008]

KLKB1: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency); also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Belongs to the peptidase S1 family. Plasma kallikrein subfamily.

Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.21.34

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; fibrinolysis; positive regulation of fibrinolysis; zymogen activation; proteolysis; blood coagulation; blood coagulation, intrinsic pathway; plasminogen activation; Factor XII activation

Disease: Prekallikrein Deficiency

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