Full Product Name
SLC9A3 Antibody
Product Gene Name
anti-SLC9A3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48764
Species Reactivity
Human, Mouse, Rat
Concentration
1.0mg/ml (lot specific)
Other Notes
Small volumes of anti-SLC9A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SLC9A3 antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SLC9A3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001271280.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001284351.2
[Other Products]
UniProt Primary Accession #
P48764
[Other Products]
UniProt Secondary Accession #
Q3MIW3; B7ZKR2; E9PF67[Other Products]
UniProt Related Accession #
P48764[Other Products]
Molecular Weight
91,904 Da
NCBI Official Full Name
sodium/hydrogen exchanger 3 isoform 2
NCBI Official Synonym Full Names
solute carrier family 9 member A3
NCBI Official Symbol
SLC9A3??[Similar Products]
NCBI Official Synonym Symbols
NHE3; DIAR8; NHE-3
??[Similar Products]
NCBI Protein Information
sodium/hydrogen exchanger 3
UniProt Protein Name
Sodium/hydrogen exchanger 3
UniProt Synonym Protein Names
Na(+)/H(+) exchanger 3
Protein Family
Sodium/hydrogen exchanger
UniProt Gene Name
SLC9A3??[Similar Products]
UniProt Synonym Gene Names
NHE-3??[Similar Products]
NCBI Summary for SLC9A3
The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]
UniProt Comments for SLC9A3
NHE3: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5p15.33
Cellular Component: apical plasma membrane; brush border; brush border membrane; cell surface; plasma membrane
Molecular Function: PDZ domain binding; potassium:hydrogen antiporter activity; protein binding; sodium:hydrogen antiporter activity
Biological Process: ion transport; regulation of intracellular pH
Disease: Diarrhea 8, Secretory Sodium, Congenital
Research Articles on SLC9A3
1. Expression of NHE3 and DRA was reduced with high tacrolimus levels and impaired renal function after intestinal transplantation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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