Product Name
SLC9A3, Polyclonal Antibody
Popular Item
Full Product Name
SLC9A3 Antibody
Product Synonym Names
MGC126718; MGC126720; Na(+)/H(+) exchanger 3; NHE 3; NHE-3; NHE3; SL9A3_HUMAN; SLC9A 3; Slc9a3; Sodium/hydrogen exchanger 3; Sodium/hydrogen exchanger, apical epithelial; Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; Solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3
Product Gene Name
anti-SLC9A3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48764
Species Reactivity
Human, Mouse, Rat
Specificity
SLC9A3 antibody detects endogenous levels of total SLC9A3
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human SLC9A3
Subcellular Location
Membrane. In intestinal epithelial cells, localizes to the ileal brush border.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-SLC9A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC9A3 antibody
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.
Subunit Structure: Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity). Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Interacts with AHCYL1; the interaction is required for SLC9A3 activity (PubMed:18829453, PubMed:20584908).
Post-translational Modifications: Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.
Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Applications Tested/Suitable for anti-SLC9A3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SLC9A3 antibody
WB: 1:1000-3000
Western Blot (WB) of anti-SLC9A3 antibody
Western blot analysis SLC9A3 using COLO205 whole cell lysates
NCBI/Uniprot data below describe general gene information for SLC9A3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001271280.1
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NCBI GenBank Nucleotide #
NM_001284351.2
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UniProt Primary Accession #
P48764
[Other Products]
UniProt Secondary Accession #
Q3MIW3; B7ZKR2; E9PF67[Other Products]
UniProt Related Accession #
P48764[Other Products]
Molecular Weight
Observed: 93 kDa
Predicted: 93 kDa
NCBI Official Full Name
sodium/hydrogen exchanger 3 isoform 2
NCBI Official Synonym Full Names
solute carrier family 9 member A3
NCBI Official Symbol
SLC9A3??[Similar Products]
NCBI Official Synonym Symbols
NHE3; DIAR8; NHE-3
??[Similar Products]
NCBI Protein Information
sodium/hydrogen exchanger 3
UniProt Protein Name
Sodium/hydrogen exchanger 3
UniProt Synonym Protein Names
Na(+)/H(+) exchanger 3
Protein Family
Sodium/hydrogen exchanger
UniProt Gene Name
SLC9A3??[Similar Products]
UniProt Synonym Gene Names
NHE-31 PublicationManual assertion based on opinion iniRef.1??[Similar Products]
NCBI Summary for SLC9A3
The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]
UniProt Comments for SLC9A3
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.
Research Articles on SLC9A3
1. We demonstrate that NHE3-799C is a common variant of NHE3 that is enriched in Asian populations; however its presence seems to have limited clinical significance in humans and is not associated with compromised function or abnormal transport regulation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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