Product Name
KLKB1, cDNA Clone
Full Product Name
KLKB1 cDNA Clone
Product Gene Name
KLKB1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgattttat tcaagcaagc aacttatttc atttccttgt ttgctacagt ttcctgtgga tgtctgactc aactctatga aaacgccttc ttcagaggtg gggatgtagc ttccatgtac accccaaatg cccaatactg ccagatgagg tgcacattcc acccaaggtg tttgctattc agttttcttc cagcaagttc aatcaatgac atggagaaaa ggtttggttg cttcttgaaa gatagtgtta caggaaccct gccaaaagta catcgaacag gtgcagtttc tggacattcc ttgaagcaat gtggtcatca aataagtgct tgccatcgag acatttataa aggagttgat atgagaggag tcaattttaa tgtgtctaag gttagcagtg ttgaagaatg ccaaaaaagg tgcaccaata acattcgctg ccagtttttt tcatatgcca cgcaaacatt tcacaaggca gagtaccgga acaattgcct attaaagtac agtcccggag gaacacctac cgctataaag gtgctgagta acgtggaatc tggattctca ctgaagccct gtgccctttc agaaattggt tgccacatga acatcttcca gcatcttgcg ttctcagatg tggatgttgc cagggttctc actccagatg cttttgtgtg tcggaccatc tgcacctatc accccaactg cctcttcttt acattctata caaatgtatg gaaaatcgag tcacaaagaa atgtttgtct tcttaaaaca tctgaaagtg gcacaccaag ttcctctact cctcaagaaa acaccatatc tggatatagc cttttaacct gcaaaagaac tttacctgaa ccctgccatt ctaaaattta cccgggagtt gactttggag gagaagaatt gaatgtgact tttgttaaag gagtgaatgt ttgccaagag acttgcacaa agatgattcg ctgtcagttt ttcacttatt ctttactccc agaagactgt aaggaagaga agtgtaagtg tttcttaaga ttatctatgg atggttctcc aactaggatt gcgtatggga cacaagggag ctctggttac tctttgagat tgtgtaacac tggggacaac tctgtctgca caacaaaaac aagcacacgc attgttggag gaacaaactc ttcttgggga gagtggccct ggcaggtgag cctgcaggtg aagctgacag ctcagaggca cctgtgtgga gggtcactca taggacacca gtgggtcctc actgctgccc actgctttga tgggcttccc ctgcaggatg tttggcgcat ctatagtggc attttaaatc tgtcagacat tacaaaagat acacctttct cacaaataaa agagattatt attcaccaaa actataaagt ctcagaaggg aatcatgata tcgccttgat aaaactccag gctcctttga attacactga attccaaaaa ccaatatgcc taccttccaa aggtgacaca agcacaattt ataccaactg ttgggtaacc ggatggggct tctcgaagga gaaaggtgaa atccaaaata ttctacaaaa ggtaaatatt cctttggtaa caaatgaaga atgccagaaa agatatcaag attataaaat aacccaacgg atggtctgtg ctggctataa agaaggggga aaagatgctt gtaagggaga ttcaggtggt cccttagttt gcaaacacaa tggaatgtgg cgtttggtgg gcatcaccag ctggggtgaa ggctgtgccc gcagggagca acctggtgtc tacaccaaag tcgctgagta catggactgg attttagaga aaacacagag cagtgatgga aaagctcaga tgcagtcacc agcatga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of KLKB1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for KLKB1. It may not necessarily be applicable to this product.
NCBI Accession #
BC117349
[Other Products]
UniProt Secondary Accession #
Q17RE8; Q17RE9; Q4W5C3; A6NH96; B2R8H9[Other Products]
UniProt Related Accession #
P03952[Other Products]
Molecular Weight
71,370 Da
NCBI Official Full Name
Homo sapiens kallikrein B, plasma (Fletcher factor) 1, mRNA
NCBI Official Synonym Full Names
kallikrein B1
NCBI Official Symbol
KLKB1??[Similar Products]
NCBI Official Synonym Symbols
PKK; PPK; KLK3; PKKD
??[Similar Products]
NCBI Protein Information
plasma kallikrein
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikrein; PKK
Protein Family
Plasma kallikrein
UniProt Gene Name
KLKB1??[Similar Products]
UniProt Synonym Gene Names
KLK3; PKK??[Similar Products]
UniProt Entry Name
KLKB1_HUMAN
NCBI Summary for KLKB1
This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
UniProt Comments for KLKB1
KLKB1: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency); also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Protein type: Protease; Secreted, signal peptide; EC 3.4.21.34; Secreted
Chromosomal Location of Human Ortholog: 4q35
Cellular Component: extracellular region; extracellular space; plasma membrane
Molecular Function: protein binding; serine-type endopeptidase activity
Biological Process: blood coagulation, intrinsic pathway; extracellular matrix disassembly; Factor XII activation; plasminogen activation; positive regulation of fibrinolysis; proteolysis; zymogen activation
Disease: Prekallikrein Deficiency
Research Articles on KLKB1
1. KLKB1 mRNA expression is a putative molecular biomarker in chronic lymphocytic leukemia.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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