EC 3.4.21.34; Fletcher factor; kininogenin; KLK3

For Research Use Only. Not for use in diagnostic procedures.

KLKB1 (heavy chain, Cleaved-Arg390) antibody detects endogenous levels of fragment of activated KLKB1 resulting from cleavage adjacent to Arg390.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-KLKB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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Western Blot (WB), ELISA (EIA)

WB: 1:500-1:1000
ELISA: 1:10000

Western blot analysis of extracts from HeLa cells, using KLKB1 (heavy chain, Cleaved-Arg390) antibody.

71,370 Da

kallikrein B1

plasma kallikrein

Plasma kallikrein

KLK3; PKK??[Similar Products]

This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Chung D.W., Biochemistry 25:2410-2417(1986). Yu H., Genomics 69:225-234(2000). McMullen B.A., Biochemistry 30:2050-2056(1991).

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