Product Name
SLC5A1, Polyclonal Antibody
Full Product Name
SLC5A1 (Sodium/Glucose Cotransporter 1, Na(+)/glucose Cotransporter 1, High Affinity Sodium-glucose Cotransporter, Solute Carrier Family 5 Member 1, NAGT, SGLT1)
Product Synonym Names
Anti -SLC5A1 (Sodium/Glucose Cotransporter 1, Na(+)/glucose Cotransporter 1, High Affinity Sodium-glucose Cotransporter, Solute Carrier Family 5 Member 1, NAGT, SGLT1)
Product Gene Name
anti-SLC5A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 22; NC_000022.10 (32439019..32509016). Location: 22q13.1; 22q12.3
3D Structure
ModBase 3D Structure for P13866
Species Reactivity
Human, Mouse
Specificity
Recognizes human SLC5A1. Species Crossreactivity: mouse.
Purity/Purification
Purified
Purified.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full-length human SLC5A1 (aa1-664, AAI46581.1)
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, 11c7entrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-SLC5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC5A1 antibody
Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally-related substances across cellular membranes. Two families of glucose transporter have been identified: the facilitated-diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters' (Wright et al., 1994 [PubMed 7823022]). The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells.
Product Categories/Family for anti-SLC5A1 antibody
Antibodies; Abs to Transport Proteins
Applications Tested/Suitable for anti-SLC5A1 antibody
Western Blot (WB)
Application Notes for anti-SLC5A1 antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for SLC5A1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
P13866
[Other Products]
UniProt Secondary Accession #
B2R7E2[Other Products]
UniProt Related Accession #
P13866[Other Products]
Molecular Weight
73,498 Da[Similar Products]
NCBI Official Full Name
SLC5A1
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/glucose cotransporter), member 1
NCBI Official Symbol
SLC5A1??[Similar Products]
NCBI Official Synonym Symbols
NAGT; SGLT1; D22S675
??[Similar Products]
NCBI Protein Information
sodium/glucose cotransporter 1; OTTHUMP00000028869; Na+/glucose cotransporter 1; high affinity sodium-glucose cotransporter
UniProt Protein Name
Sodium/glucose cotransporter 1
UniProt Synonym Protein Names
High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
Protein Family
Sodium/glucose cotransporter
UniProt Gene Name
SLC5A1??[Similar Products]
UniProt Synonym Gene Names
NAGT; SGLT1??[Similar Products]
UniProt Entry Name
SC5A1_HUMAN
NCBI Summary for SLC5A1
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption.
UniProt Comments for SLC5A1
SLC5A1: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Expressed mainly in intestine and kidney. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: integral to plasma membrane; brush border membrane; apical plasma membrane; plasma membrane; intercellular junction
Molecular Function: protein binding; glucose:sodium symporter activity
Biological Process: hexose transport; sodium ion transport; carbohydrate metabolic process; pathogenesis; glucose transport; metanephros development; transmembrane transport; intestinal absorption
Disease: Glucose/galactose Malabsorption
Research Articles on SLC5A1
1. Polyphenols, phenolic acids and tannins from strawberry and apple are potent inhibitors of GLUT2 and SGLT1 at concentrations predicted after dietary ingestion.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
