Dual specificity protein phosphatase 15; VH1-related member Y; Vaccinia virus VH1-related dual-specific protein phosphatase Y; DUSP15; C20orf57; VHY

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This DUSP15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human DUSP15.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-DUSP15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene belongs to the
non-receptor class of the protein-tyrosine phosphatase family. The
encoded protein has both protein-tyrosine phophatase activity and
serine/threonine-specific phosphatase activity, and therefore is
known as a dual specificity phosphatase. Three transcript variants
encoding two different isoforms have been found for this gene.

Metabolism; Signal Transduction

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

WB~~1:1000

DUSP15 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the DUSP15 antibody detected the DUSP15 protein (arrow).

DUSP15 Antibody (Center) (MBS9209799)immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DUSP15 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

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dual specificity phosphatase 15

dual specificity protein phosphatase 15

Dual specificity protein phosphatase 15

C20orf57; VHY??[Similar Products]

DUS15_HUMAN

The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DUSP15: belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: cytoplasm; plasma membrane

Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: transforming growth factor beta receptor signaling pathway; positive regulation of JNK cascade; protein amino acid dephosphorylation; regulation of cell proliferation

Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Yoon, T.S., et al. Proteins 61(3):694-697(2005)
Alonso, A., et al. J. Biol. Chem. 279(31):32586-32591(2004)
Alonso, A., et al. J. Biol. Chem. 279(31):32586-32591(2004)

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