Human Insulin receptor substrate 4 (IRS4) ELISA kit; IRS-4; PY160; ; insulin receptor substrate 4

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of IRS4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9337132 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the insulin receptor substrate 4 (IRS4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IRS4. The ELISA analytical biochemical technique of the MBS9337132 kit is based on IRS4 antibody-IRS4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IRS4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IRS4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

133,768 Da

insulin receptor substrate 4

insulin receptor substrate 4; pp160; phosphoprotein of 160 kDa; 160 kDa phosphotyrosine protein

Insulin receptor substrate 4

IRS-4; py160; pp160??[Similar Products]

IRS4_HUMAN

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]

IRS4: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xq22.3

Cellular Component: plasma membrane; cytosol

Molecular Function: signal transducer activity; protein binding; SH3/SH2 adaptor activity; phosphoinositide 3-kinase binding; insulin receptor binding

Biological Process: regulation of lipid metabolic process; positive regulation of signal transduction; insulin receptor signaling pathway; signal transduction

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