MYL2 Human; Myosin Light Chain 2 Human Recombinant; MLC2; CMH10; MYL-2; Myosin regulatory light chain 2; MYOSIN LIGHT CHAIN REGULATORY VENTRICULAR; DKFZp779C0562; MYL2; MLC-2v; MLC-2

For Research Use Only. Not for use in diagnostic procedures.

E Coli

Greater than 95.0% as determined by SDS-PAGE.

MYL2 solution containing 20mM Tris pH-8 pH-7.4, 20% glycerol and 5mM CaCl2.
Sterile filtered colorless solution.

Small volumes of MYL2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: MYL2 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 186 amino acids (1-166) and having a molecular mass of 20.9 kDa. MYL2 is fused to a 20 amino acid His Tag fused at N-terminus and purified by proprietary chromatographic techniques.

Introduction: MYL2 regulatory light chain is associated with cardiac myosin beta (or slow) heavy chain. Ca+ activates the phosphorylation of regulatory light chain that in turn activates contraction. Mutations in this MYL2 gene are related with mid-left ventricular chamber type hypertrophic cardiomyopathy. MYL2 is an essential protein that plays a role in the regulation of myosin ATPase activity in smooth muscle. MYL2 phosphorylation is regulated by ROCK and MLC kinase and is involved in platelet biogenesis by controlling proplatelet formation and fragmentation.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Myosin Light Chain

18,789 Da

myosin, light chain 2, regulatory, cardiac, slow

myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; MLC-2v; RLC of myosin; cardiac ventricular myosin light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow; regulatory light chain of myosin; slow cardiac myosin regulatory light chain 2

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

MLC-2; MLC-2v??[Similar Products]

MLRV_HUMAN

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

Protein type: Contractile

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: sarcomere; cytoskeleton; myofibril; cytosol; myosin complex; A band; actin cytoskeleton

Molecular Function: actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding

Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; cardiac muscle contraction; post-embryonic development; muscle filament sliding

Disease: Cardiomyopathy, Familial Hypertrophic, 10

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