Product Name
TNFRSF13B, Monoclonal Antibody
Full Product Name
Rat Anti-Mouse TNFRSF13B
Product Synonym Names
Tnfrsf13b; Taci; 1200009E08Rik
Product Gene Name
anti-TNFRSF13B antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000077.6 (61126741..61149373). Location: 11 B2; 11
3D Structure
ModBase 3D Structure for Q9ET35
Reconstitution
Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
Preparation and Storage
Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TNFRSF13B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNFRSF13B antibody
TACI, transmembrane activator and CAML-interactor, is a member of the TNF receptor superfamily (TNFRSF). Within the TNFRSF, it shares the highest homology with BCMA. TACI and BCMA both bind APRIL and BLyS/BAFF, members of the TNF superfamily. TACI is expressed on the cell surface of B cells and activated, but not resting, T cells. Human and mouse TACI share 54% amino acid sequence identity.
Applications Tested/Suitable for anti-TNFRSF13B antibody
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for TNFRSF13B. It may not necessarily be applicable to this product.
NCBI Accession #
NP_067324.1
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NCBI GenBank Nucleotide #
NM_021349.1
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UniProt Primary Accession #
Q9ET35
[Other Products]
UniProt Secondary Accession #
Q9DBZ3[Other Products]
UniProt Related Accession #
Q9ET35[Other Products]
Molecular Weight
26,947 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 13B
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 13b
NCBI Official Symbol
Tnfrsf13b??[Similar Products]
NCBI Official Synonym Symbols
Taci; 1200009E08Rik
??[Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 13B; transmembrane activator and CAML interactor; transmembrane activator and calcium-modulating and cyclophilin ligand interactor
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 13B
UniProt Synonym Protein Names
Transmembrane activator and CAML interactor
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
Tnfrsf13b??[Similar Products]
UniProt Synonym Gene Names
Taci??[Similar Products]
UniProt Entry Name
TR13B_MOUSE
UniProt Comments for TNFRSF13B
Function: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity
By similarity. Ref.3 Ref.4
Subunit structure: Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus
By similarity.
Subcellular location: Membrane; Single-pass type III membrane protein
Probable.
Sequence similarities: Contains 2 TNFR-Cys repeats.
Research Articles on TNFRSF13B
1. Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI activation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
